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The growing use of GLP-1 receptor agonists may affect the interpretation of oncological FDG PET-CT scans, new research presented today at the 38th Annual Congress of the European Association of Nuclear Medicine (EANM'25) has revealed
Betting on a widespread GLP-1 adoption, some private equity investors are practicing an investor version of the Ozempic diet and are refraining from investing in consumer companies (such as snackmakers, alcohol brands, or restaurant chains) that could be negatively impacted by the GLP-1 boom, believing that profits will get squeezed as GLP-1 users no longer crave them and/or obesity rates fall
A related concern is the body composition consequence of rebound: GLP-1 RA-induced weight loss includes a proportional loss of fat-free mass, and weight regained after discontinuation returns disproportionately as fat a sarcopenic recomposition pattern that is physiologically expected during weight cycling and is only now being formally quantified in the GLP-1 RA context (Tinsley & Heymsfield, 2024)
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Moreover, activation of the anti-oxidative defense system, such as SLC7A11 or GPX4 upregulation, confers protection against DKD by suppressing tubular ferroptosis (193, 194)